Department of Medicine

Cardiovascular Medicine Faculty

Marian C. Limacher, MD, FACC Division of Cardiovascular Medicine Professor of Medicine Director, Advanced Postgraduate Program in Clinical Investigation; Medical Director, Shands Cardiovascular Clinic e-mail: limacmc@medicine.ufl.edu 1600 SW Archer Road/Box 100277 Gainesville, FL 32610-0277 352 846 1228/FAX 352 846 1217

Dr. Marian Limacher has served as the APPCI program director since its inception. She is an active clinician, researcher, and mentor. She is a Professor of Medicine in the Division of Cardiovascular Medicine at the University of Florida.

She has extensive research experience and is currently the PI for the University of Florida Clinical Center for the Women’s Health Initiative. She is the Co-PI for the R18 funded clinical trial of obesity treatment in rural women, “Treatment of Obesity in Underserved Rural Settings” (TOURS), Michael Perri, PhD, PI. She is the Chair of the Women’s Health Initiative Morbidity and Mortality Committee. She is also the site PI for several WHI substudies, WHIMS, WHISCA, and BBD as well as the site PI for two multi-center clinical trials of the treatment of stable coronary disease patients, Prevention of Events with Angiotensin Converting Enzyme Inhibition (PEACE) and ONTARGET/TRANSCEND.

She practices clinical cardiology serving as an attending cardiologist on the in-patient and consult services of Shands Hospital at the University of Florida and as an attending echocardiographer at both Shands Hospital and the Malcom Randall Veterans Affairs Medical Center in Gainesville, Florida.

She was awarded the Health Center Faculty Prize for Clinical Science in 2000, and the UFRF Professorship Award in 2005.

Training:

Academic Interests:

Dr. Limacher is the Principal Investigator for the UF Clinical Center for the Women’s Health Initiative. She is co-PI for the clinical trial, “Treatment of Obesity in Underserved Rural Settings”. She directs the Advanced Postgraduate Program in Clinical Investigation (NIH funded K30 program) at the University of Florida, which provides a didactic curriculum and mentoring program in clinical research career development for faculty and senior fellows. She is a past member of the Board of Trustees of the American College of Cardiology and remains active on committees for the ACC, AHA and American Society of Echocardiography.

Clinical Interests:

Echocardiography; Preventive Cardiology; Heart Disease in Women

Representative Publications:

1. Perri MG, Anton SD, Durning PE, Ketterson TU, Sydeman SJ, Berlant NE, Kanasky WF Jr, Newton RL Jr, Limacher MC, Martin AD. Adherence to exercise prescriptions: Effects of prescribing moderate versus higher levels of intensity and frequency. Health Psychology 2002;21:452-458.
2. Wassertheil-Smoller S, Hendrix S, Limacher M, Heiss G, Kooperberg C, Baird A, Kotchen T, Curb JD, Black H, Rossouw JE, Aragaki A, Safford M, Stein E, Laowattana S, Mysiw JW. Effect of estrogen plus progestin on stroke in postmenopausal women: The Women’s Health Initiative: a randomized trial. JAMA 2003; 289: 2673-2684
3. The Women’s Health Initiative Steering Committee. Anderson G (Chair, Writing Group), Limacher M (Co-Chair, Writing Group). Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. The Women’s Health Initiative Randomized Controlled Trial. JAMA 2004; 291:1701-1712
4. Duncan GE, Anton SD, Sydeman SJ, Newton RL, Corsica JA, Dunning PE, Ketterson TU, Martin AD, Limacher MC, Perri MG. Prescribing Exercise at varied levels of intensity and frequency: A randomized trial. Arch Intern Med 2005: 165: 1-8
5. Howard BV, Van Horn L, Hsia J, Manson JE, Stefanick ML, Wassertheil-Smoller S,Kuller LH, LaCroix AZ,Langer RD, Lasser NL, Lewis CE, Limacher MC, Margolis KL, Mysiw J, Ockene JK, Parker LM, Perri MG, Phillips L, Prentice RL, Robbins J, Rossouw JE, Sarto GE, Schatz IJ, Snetselaar LG, Stevens VJ, Tinker LF, Trevisan M, Vitolins MZ, Anderson GL, Assaf AR, Bassford T, Beresford SA, Black HR, Brunner RL, Brzyski RG, Caan B, Chlebowski RT, Gass M, Granek I, Greenland P, Hays J, Heber D, Heiss G, Hendrix, SL, Hubbell FA, Johnson KC, Kotchen JM. Low-Fat Dietary Pattern and Risk of Cardiovascular Disease: The Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295:655-666