Cardiovascular Medicine
Cardiovascular Medicine Faculty
| Alexandra R. Lucas, M.D., FRCPC Division of Cardiovascular Medicine Ethel Smith Chair in Vasculitis Research Professor of Medicine Director Vascular Research, Malcom Randall VA Medical Center e-mail: alexandra.lucas@medicine.ufl.edu Office: 352-392-0092 Fax: 352-392-7424 |
Training:
| Degree Program |
Institution | Field/Specialty |
| BSc | McGill University | Honours Biochemistry |
| MD | University of Alberta School of Medicine | |
| Residency/Fellowship | University of Alberta | Internal Medicine, Cardiology |
| Research Fellowship | Tufts’ New England Medical Center | Cardiovascular Medicine |
Academic Interests:
Dr. Lucas has just moved to the University of Florida from the Robarts Research Institute and University of Western Ontario in London Ontario Canada where she has been a principal investigator studying of monocytes and T lymphocytes in vascular disease. Dr Lucas is also co-inventor and co-founding scientist for Viron Therapeutics, Inc., a Biotechnology company that is now in clinical trial analyzing viral anti-inflammatory proteins as a new class of therapeutic agents. Dr Lucas is a practicing interventional cardiologist. Dr Lucas runs an active basic research lab in vascular inflammatory research has been an active member of the Canadian Society for Atherosclerosis and Thrombosis Board and has been Editor-in-Chief and on the editorial board of several journals. Dr Lucas also directs an annual medical mission to Fte Liberte in Haiti.
Basic Science and Clinical Interests:
Vascular innate immune responses, unstable plaque, acute coronary syndromes, transplant vasculopathy, vasculitis, T lymphocyte, monocyte / macrophage, serpins, chemokines, apoptosis, optical analysis of vascular disease, interventional cardiology.
Representative Publications:
- Lucas AR, and McFadden G. Secreted immunomodulatory viral proteins as novel biotherapeutics. Immunology 2004;173: 4765-74.
- Dai E, Viswanathan K, Sun YM, Li X, Liu L, Togonu-Bickersteth B, Richardson J, Macaulay C, Nash P, Turner P, Nazarian S, Moyer R, McFadden G, Lucas AR. Identification of myxomaviral serpin reactive site loop sequences that regulate innate immune responses. J Biol Chem 2006, 281(12):8041-8050.
- Viswanathan K, Liu L, Vaziri S, Richardson J, Togonu-Bickersteth B, Vatsya P, Christov A, and Lucas AR. Myxoma viral serpin, Serp-1, a unique interceptor of coagulation and innate immune pathways. Thromb Haemost 2006, 95:499-510.
- Liu LY, Lalani A, Dai E, Seet B, Macauley C, Singh R, Fan L, McFadden G, Lucas AR: A viral anti-inflammatory chemokine binding protein, M-T7, reduces intimal hyperplasia after vascular injury. J Clin Invest 2000;105:1613-1621.
- Christov A, Korol R, Dai E, Liu L, Guan H, Bernards MA, Cavers PB, Susko D, Lucas AR. In vivo optical analysis of quantitative change in collagen and elastin during arterial remodeling.. Photochem Photobiol 2005, 81: 457-466.
- Lucas A, Korol R, Pepine C. Inflammation in Atherosclerosis. Circulation 2006, 113:(in press).
- Viswanathan K, Bot I, Liu L, Dai E, Turner PC, Togonu-Bickersteth J, Pang B, Li Y, Biessen EA, Moyer R and Lucas AR. Viral cross-class serpin inhibits apoptosis, inflammation and atherosclerosis. In Modulation of Atherothrombotic Factors: Novel Strategies for Plaque Stabilization. Print Partners Ipstamp, Enschede, The Netherlands 2005:pg 61-76. Published as part of a Thesis submission by Ilze Bot.
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