Department of Medicine

Cardiovascular Medicine Faculty

Yejia Song, MD Associate Scientist Division of Cardiovascular Medicine ARB, R5-140 Box 100277 e-mail: songy@medicine.ufl.edu Tel: (352)392-3078 Fax: (352)392-5885

Dr. Song graduated from Shanghai Second Medical University. He completed his residency in internal medicine at Haudong Hospital and received his research training in electrophysiology at State University of New York. His research interests include cardiac cellular electrophysiology, myocardial contractility, and intracellular signal transduction.

Training:

Research Interests:

Dr. Song’s major research field is cardiac cellular electrophysiology. Specifically, he is interested in the adrenergic, muscarinic and purinergic receptor-mediated regulation of cardiac membrane potentials and currents and in the ionic mechanisms underlying cardiac arrhythmic activities. His studies are conducted on single atrial and ventricular myocytes, using current- and voltage-clamp techniques. Recently, his study has been focusing on the role of persistent sodium current in abnormal automaticity and triggered activity of cardiac myocytes. The goals of this study are to determine the contribution of persistent sodium current to ectopic activity and to evaluate the potential anti-arrhythmic value of blocking this current. In addition, he is also interested in the regulation of contractile function of single cardiac myocytes. Dr. Song welcomes research collaborations with clinical physicians and basic scientists.

Representative Publications:

1. Song Y, Shryock JC, Wagner S, Maier LS, Belardinelli L. Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J Pharmacol Exp Ther. 2006;318:1-9.
2. Song Y, Shryock JC, Wu L, Belardinelli L. Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes. J Cardiovasc Pharmacol. 2004;44:192-199.
3. Song Y, Wu L, Shryock JC, Belardinelli L. Selective attenuation of isoproterenol-stimulated arrhythmic activity by a partial agonist of A1 adenosine receptor. Circulation. 2002;105:118-123.
4. Song Y, Shryock JC, Knot HJ, Belardinelli L. Greater attenuation by adenosine of arrhythmogenic than of inotropic action of isoproterenol on cardiac myocytes. Am J Physiology. 2001;280:H2789-H2795.
5. Song Y, Vassalle M. Arrhythmogenic mechanisms of norepinephrine in depolarized single ventricular myocytes. G Ital Cardiol. 1999;29(Suppl 5):81-85.
6. Song Y, Shryock JC, Belardinelli L. Potentiating effect of acetylcholine on stimulation by isoproterenol of L-type Ca2+ current and arrhythmogenic triggered activity in guinea pig ventricular myocytes. J Cardiovas Electrophysiol. 1998;9:718-726.
7. Song Y, Srinivas M, Belardinelli L. Nonspecific inhibition of adenosine-activated K+ current by glibenclamide in guinea pig atrial myocytes. Am J Physiol. 1996;271:H2430-H2437.
8. Song Y, Belardinelli L. Electrophysiological and functional effects of adenosine on ventricular myocytes of various mammalian species. Am J Physiol. 1996;271:C1233-C1243.
9. Song Y, Liu QY, Vassalle M. On the antiarrhythmic actions of magnesium in single guinea pig ventricular myocytes. Clin Exp Pharmacol Physiol. 1996;23:830-838.
10. Song Y, Shryock J, Belardinelli L. Modulation of cardiomyocyte membrane currents by A1 adenosine receptors. In: Belardinelli L, Pelleg A, eds. Adenosine and adenine nucleotides: from molecular biology to integrative physiology. Norwell, Massachusetts: Kluwer Academic; 1995. p. 97-102.
11. Song Y, Belardinelli L. ATP promotes development of afterdepolarizations and triggered activity in cardiac myocytes. Am J Physiol. 1994;267:H2005-H2011.
12. Song Y, Thedford S, Lerman B, Belardinelli L. Adenosine-sensitive afterdepolarizations and triggered activity in isolated guinea pig ventricular myocytes. Circ Res. 1992;70:743-753.
13. Song Y, Vassalle M. On the mechanism of depolarization-induced pacemaker potential in isolated guinea pig ventricular myocytes. New Trends in Arrhythmias. 1992;8(4):593-603.