Endocrinology, Diabetes & Metabolism

Endocrinology, Diabetes & Metabolism Faculty

Nicholas E. Simpson, Ph.D.,
Research Assistant Professor of Medicine

Original Observations in Refereed Journals:

  • Evelhoch JL, Bissery M-C, Chabot GG, Simpson NE, McCoy CL, Heilbrun LK, Corbett TH.  Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy.  Cancer Research.  48:4749-4755, 1988.
  • DeNeve W, Evelhoch JL, Everett C, Simpson NE, Bissery M-C, Corbett TH, Valeriote F.  Interaction between flavone acetic acid (LM-975, NSC 347512) and radiation in Glasgow’s Osteogenic Sarcoma in vivo.  Int. J. Radiat. Oncol. Biol. Phys.  18(6):1359-1365, 1990.
  • Larcombe McDouall JB, Mattiello J, McCoy CL, Simpson NE, Sayedsadr M, Evelhoch JL.  Size dependence of regional tumor blood flow in murine tumors using deuterium magnetic resonance imaging.  Int. J. Radiat. Biol.  60:109-113, 1991.
  • Evelhoch JL, Larcombe-McDouall JB, Mattiello J, Simpson NE.  Measurement of relative regional tumor blood flow in mice by deuterium nuclear magnetic resonance imaging.  Mag. Reson. Med.  24:42-52, 1992.
  • Jalukar J, Penney DG, Crowley M, Simpson NE.  Magnetic resonance imaging of the rat brain following acute carbon monoxide poisoning.  J. Appl. Toxicol.  12/6:407-414, 1992.
  • Simpson NE, He Z, Evelhoch JL.  Deuterium NMR tissue perfusion measurements using the tracer uptake approach: I. Optimization of methods.  Mag. Reson. Med.  42:42-52, 1999.
  • Simpson NE, Evelhoch JL. Deuterium NMR tissue perfusion measurements using the tracer uptake approach: II. Comparison with microspheres in tumors.  Mag. Reson. Med.  42:240-247, 1999.
  • Simpson NE, Bennett LK, Papas KK, Sambanis A, Constantinidis I. Effects of pH on murine insulinoma bTC3 cells.  Bioch. Biophys. Res. Comm., 273:937-941, 2000.
  • Akins A, Simpson N, Constantinidis I.  The metabolic activity of encapsulated b-TC-tet cells.  J. Undergrad. Res. in Bioengin.  1/1:9-21, 2001.
  • McConathy J, Martarello L, Simpson NE, Simpson CP, Malveaux EJ, Yu WP, Camp VM, Bowers GD, Olson JJ, Goodman MM.  Uptake profiles of six 18F-labeled amino acids for tumor imaging: Comparison of in vitro and in vivo uptake of branched chain and cyclobutyl amino acids by 9L gliosarcoma tumor cells. J. Nucl. Med. 43(5):41P-41P 149, Suppl. S, 2002.
  • McConathy J, Martarello L, Malveaux EJ, Camp MV, Simpson NE, Simpson CP, Bowers GD, Olson JJ, Goodman MM.  Radiolabeled amino acids for tumor imaging with PET: Radiosynthesis and biological evaluation of 2-amino-3[18F] fluoro-2-methylpropanoic acid and 3-[18F] fluoro-2-methyl-(methylamino) propanoic acid.  J. Med. Chem.  45(11): 2240-2249, 2002.
  • Martarello L, McConathy J, Camp VM, Malveaux EJ, Simpson NE, Simpson CP, Olson JJ, Bowers GD, Goodman MM.  Synthesis of syn- and anti-1-amino-3[18F] fluoromethyl-cyclobutane-1-carboxylic acid (FMACBC), potential PET ligands for tumor detection.  J. Med. Chem. 45(11): 2250-2259, 2002.
  • McConathy J, Martarello L, Malveaux EJ, Camp VM, Simpson NE, Simpson CP, Bowers GD, Zhang Z, Olson JJ, Goodman MM.  Synthesis and evaluation of 2-amino-4-[18F] fluoro-2-methylbutanoic acid (FAMB): relationship of amino acid transport to tumor imaging properties of branched fluorinated amino acids.  Nucl. Med. Biol. 30: 477-490, 2003.
  • Grant SC, Simpson NE, Blackband SJ, Constantinidis I.  MR microscopy in alginate beads as a tool for developing artificial organs.  NHMFL Reports. 10:10-11, 2003.
  • Simpson NE, Grant SC, Blackband SJ, Constantinidis I.  NMR properties of alginate microbeads.  Biomaterials.  24:4941-4948, 2003.
  • Simpson NE, Stabler CL, Sambanis A, Constantinidis I.  The role of guluronic acid-CaCl2 interaction on alginate encapsulated bTC3 cells.  Biomaterials.  25:2603-2610, 2004.
  • Oca-Cossio JA, Mao H, Khokhlova N, Kennedy CM, Kennedy JW, Stabler CL, Hao E, Sambanis A, Simpson NE, Constantinidis I.  Magnetically labeled insulin secreting cells.  Bioch. Biophys. Res. Comm. 319:569-575, 2004.
  • Simpson NE, Khokhlova N, Oca-Cossio JA, McFarlane SS, Simpson CP, Constantinidis I.  Effects of growth regulation on conditionally-transformed alginate-entrapped insulin secreting cell lines in vitro.  Biomaterials.  26:4633-4641, 2005.
  • Grant SC, Celper S, Gauffin-Holmberg I, Simpson NE, Blackband SJ, Constantinidis I.  Alginate assessment by NMR microscopy.  J. Mater. Sci. Mat Med. 16:511-514, 2005.
  • Oca-Cossio J, Simpson NE, Han Z, Stacpoole PW, Constantinidis I.  Effects of alginate encapsulation on mitochondrial activity.  J. Mater. Sci. Mat. Med. 16:521-524, 2005.
  • Thelwall PE, Yemin AY, Gillian TL, Simpson NE, Kasibhatla MS, Rabbani ZN, Macdonald JM, Blackband SJ, Gamcsik MP.  Noninvasive in vivo detection of glutathione metabolism in tumors.  Cancer Res. 65:10149-10153, 2005.
  • Simpson NE, Grant SC, Gustavsson L, Peltonen V-M, Blackband SJ, Constantinidis I. Biochemical consequences of cell encapsulation a NMR study of insulin-secreting cells.  Biomaterials, 27:2577-2586, 2006.
  • Lansang C, Chitaia N, Simpson NE, Kennedy L.  Serum IGF-1 in treated Acromegaly – How normal is normal?  Pituitary, 8:135-138, 2006.
  • Simpson NE, Khokhlova N, Oca-Cossio J, Constantinidis I.  Insights into the role of anaplerosis in insulin secretion: a 13C NMR study.  Diabetologia, 49:1338-1348, 2006.
  • Simpson NE, Han Z, Berentzen KM, Sweeney CA, Oca-Cossio J, Constantinidis I, Stacpoole PW.  Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: Effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.  Mol. Genet. Met., 89:97-105, 2006.
  • Constantinidis I, Grant SC, Celper S, Gauffin-Holmberg I, Agering K, Oca-Cossio JA, Bui JD, Flint J, Hamaty C, Simpson NE, Blackband SJ. Non-invasive evaluation of alginate/poly-L-lysine/alginate microcapsules by magnetic resonance microscopy.  Biomaterials, 28:2438-2445, 2007.
  • Simpson NE, Constantinidis I.  13C NMR isotopomeric analysis and its application in the study of endocrine cell metabolism and function.  Acta Biomedica, 78:99-112, 2007.
  • Tsai YY, Oca-Cossio J, Agering K, Simpson NE, Atkinson MA, Wassserfall CH, Constantinidis I, Sigmund W.  Novel synthesis of cerium oxide nanoparticles for free radical scavenging.  Future Drugs, accepted, 2007.


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