Department of Medicine

Division of Hematology and Oncology

Carmen J. Allegra, MD Division of Hematology/Oncology Professor and Division Chief University of Florida Shands Cancer Center Associate Director for Clinical & Translational Research, UFSCC 1600 SW Archer Road/Box 100277 Gainesville, FL 32610-0277 (352) 273-7832/FAX (352) 273-7849

Carmen J. Allegra, M.D., is a board certified medical oncologist with expertise in the study and treatment of colorectal cancer.  He is the Chief of the Division of Hematology & Oncology as well as the Associate Director for Clinical and Translational Research for the Department of Medicine and University of Florida Shands Cancer Center.  He is also co-director of the Foundation Research Program at the National Surgical Adjuvant Breast and Bowel Project (NSABP).

Training:

Clinical Interests:

Diagnosis and Treatment of  Colorectal Cancer

Research Interests:

His primary research effort is focused on developing new therapeutic strategies for patients with GI malignancies through the identification and translation of novel laboratory discoveries and therapeutic agents. This work is underpinned by new target discovery and identification of prognostic and predictive signatures required to personalize oncologic therapeutics.

Representative Publications:

• Allegra C, Blanke C, Buyse M, Goldberg R, Grothey, A, Meropol N, Saltz L, Venook A, Yothers G. and Sargent D. Endpoints in Advanced Colon Cancer Clinical Trials. Review and Proposal. J. Clin. Oncol. 2007 August 20;25(24):3572-5
• Kim GP, Colangelo L, Wieand HS, Paik SM, Kirsch I, Wolmark N and, Allegra CJ: Prognostic and Predictive Roles of High-Degree Microsatellite Instability (MSI-H) in Colon Cancer: National Cancer Institute (NCI) - - National Surgical Adjuvant Breast and Bowel Project (NSABP) Collaborative Study. J. Clinical Oncology, March, 2007
• Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett K, Kaye F and Zajac-Kaye M: Thymidylate Synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell 5:341-351, April 2004
• Johnson PG, Benson AB, Catalano P, Rao SM, O’Dwyer PJ and Allegra CJ: Thymidylate Synthase Protein Expression in Primary Colorectal Cancer: Lack of Correlation with Outcome and Response to Fluorouracil in Metastatic Disease Sites. J. Clin. Oncol. March 1;21(5): 815- 819, 2003
• Voeller D, Zajac-Kaye M, Fisher R and Allegra C: The identification of thymidylate synthase Peptide domains located in the interface region that bind thymidylate synthase mRNA. Biochem Biophys Res Commun. 2002 Sept 13;297(1):24-31