Hematology & Oncology
Division of Hematology and Oncology
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Bradley Fletcher, MD, PhD Division Hematology/Oncology Assistant Professor Malcolm Randall VA Medical Center 1600 SW Archer Road/Box 100277 Gainesville, FL 32610-0277 (352) 273-7832/FAX (352) 371-0370 |
He is a Veterans Administration Advanced Career Development Awardee, American Heart Association Career Development Awardee and Florida Biomedical Research Program NIR Awardee.
Training:
| Degree Program |
Institution | Field/Specialty |
| Internal Medicine and Heme Fellowship | Stanford | Medicine and Hematology |
| MD | UCLA | Medicine |
| PhD | UCLA | Molecular Biology |
| MS | UCSD | Biology |
Academic Interests:
His major effort is focused on biomedical research using transposons as vehicles to facilitate long-term gene expression following non-viral gene delivery. This approach has been used to treat various conditions in animal models including hemophilia, pulmonary hypertension and acute graft rejection. Recent work focuses on targeting tumor vasculature in solid tumors.
Clinical Interests::
Dr. Fletcher’s clinical activities include attending the inpatient hematology consultation service at Shands Hospital and outpatient clinical hematology and follow-up at both the Shands Hospital and the Malcom Randall Veterans Administration Medical Center.
Representative Publications:
- Fletcher BS. Development and validation of an approach to produce large-scale quantities of CpG-ethylated plasmid DNA. Microbial Biotechnology 1(1):62-67, 2008.
- Liu L, Liu H, Visner GA and Fletcher BS. Sleeping Beauty-mediated eNOS gene therapy attenuates monocrotaline-induced pulmonary hypertension in rats. FASEB J. 20(14):2594-6, 2006.
- Liu H, Liu L, Fletcher BS and Visner GA. Sleeping Beauty-based gene therapy with indoleamine 2,3-dioxygenase inhibits lung allograft fibrosis. FASEB J. 20(13):2384-6, 2006.
- Fernando S and Fletcher BS. Sleeping Beauty Transposon-mediated Nonviral Gene Therapy BioDrugs 20(4):219-229, 2006. 5.) Liu L, Mah C and Fletcher BS. Sustained FVIII expression and phenotypic correction of Hemophilia A in neonatal mice using endothelial-targeted Sleeping Beauty transposon. Mol Ther. 13(5):1006-15, 2006.