Department of Medicine

Infectious Diseases Faculty

Reuben Ramphal, M.D. Division of Infectious Diseases Professor of Medicine e-mail: ramphr@medicine.ufl.edu 1600 SW Archer Road, Box 100277 Gainesville, FL 32610-0277 352-392-2932/FAX 392-392-6481

Reuben Ramphal received his undergraduate and medical degrees from McGill University, Montreal, Canada. He did residencies in Internal Medicine and Medical Microbiology at McGill University and a Fellowship in Infectious Diseases at the University of Florida where he was trained in basic research and clinical infectious diseases.

Training:

Academic Interests:

Dr. Ramphal’s academic interests include basic laboratory investigations on the pathogenesis of Pseudomonas infections of the lungs and the role of the flagellum of Pseudomonas aeruginosa  in disease.

Clinical Interests:

Infections in Febrile neutropenia, Pseudomonas infections, Antibiotic resistance.

Representative Publications:

• Ramphal R,  Balloy V Huerre  M, Si-Tahar M and Chignard M. Toll-like receptors 2 and 4 are not involved in hypersusceptibility to acute Pseudomonas aeruginosa lung infections J. Immunology. 175:3927-34, 2005
• Verma A, Arora SK, Kuravi SK and Ramphal R. The role of specific sites in the N terminus of Pseudomonas aeruginosa flagellin and of flagellin glycosylation in the innate immune response. Infect. Immun 73: 4395-4398, 2005
• Ramphal R and Ambrose PG. Extended-spectrum Betalactamases and Clinical Outcomes: Current Data. Clin. Infect . Dis 42; S164-172, 2006
• Verma A, Schirm M, Arora SK, Thibault P, Logan S and Ramphal R.  Glycosylation of b-type Flagellin of Pseudomonas aeruginosa: Structural and Genetic Basis. J. Bacteriol. 188:4395-403, 2006
• Sonawane A, Jyot J, During R and Ramphal R. Neutrophil elastase an innate immunity effector represses flagellin in Pseudomonas  aeruginosa . Infect. Immun. 74: 6682-6689, 2006
• Sonawane A, Jyot J and Ramphal R. Pseudomonas aeruginosa LecB is involved in pilus biogenesis and protease secretion but not in adhesion to respiratory mucins. Infect. Immun. 74: 7035-7039, 2006
• Jyot J, Sonawane A, Wu W, and Ramphal R. Genetic mechanisms involved in the repression of flagellar assembly by Pseudomonas aeruginosa in human mucus. (in press, Mol. Microbiol 2007)
• Balloy B, Verma A, Kuravi, Si-Tahar M, Chignard M and Ramphal R. The role of flagellin versus motility in acute lung disease due to Pseudomonas aeruginosa (in press, J Infect Dis 2007)
• Verma A and Ramphal R. Glycosylation Islands. In the Pseudomonads Vol V . J.Ramos and A. Filloux (eds) Kluvier Press (in press 2007)
• Ramphal R. Infections due to Pseudomonas species and related organisms. In Harrison’s Principles of Internal Medicine. Chapter 145. (in press, 2007