Cellular motility requires rapid changes in the consistency and organization of the peripheral cytoplasm. To produce outward protrusions such as pseudopods and lamellipods, the actin cytoskeleton must be continually remodeled in response to intracellular and external stimuli.

Our laboratory is applying a balanced application of molecular and structural biology approaches as well as video microscopy and microinjection to determine how Cap G, ABM complexes and profilin control actin assembly. We are also exploring how anthrax toxins may affect the changes in the actin cytoskeleton associated with cell motility.

Major research themes in our laboratory are: