Department of Medicine

Faculty

I. David Weiner, M.D.

E-mail address: weineid@ufl.edu
Clinical phone (352) 392-3576
Clinical fax: (352) 392-3581
Research phone: (352) 273-5358
Research fax: (352) 271-4518

Dr. Weiner was awarded his M.D. degree in 1984 from Vanderbilt University. He received his internal medicine training at the University of Texas Health Science Center at San Antonio under the direction of Dr. Jay H. Stein. Dr. Weiner then completed his nephrology training at Washington University and Barnes Hospital in St. Louis, under the direction of Dr. Saulo Klahr. While at Washington University Dr. Weiner pursued his research training in the laboratory of Dr. L. Lee Hamm. There, they developed techniques to measure intracellular pH in single cells of the collecting duct.

In 1990 Dr. Weiner joined the faculty at the University of Florida, in 1995 he was promoted to Associate Professor of Medicine and in 2000 he was appointed Associate Professor of Medicine and Physiology. Since joining the University of Florida, Dr. Weiner has received the American Society of Nephrology Young Investigator Award of the National Kidney Foundation and a Clinician-Scientist Award from the American Heart Association. In 1997, Dr. Weiner was elected to membership in the Southern Society for Clinical Investigation. In 2001 Dr. Weiner was appointed to the Department of Veterans Affairs Merit Review Subcommittee for Nephrology, and since 2003 he has served as its chairperson. In 2003, Dr. Weiner received the Exemplary Teacher Award from the University of Florida College of Medicine. He also is a Florida Research Foundation Professor for 2007-2009. Dr. Weiner also has a joint clinical appointment with the North Florida/South Georgia Veterans Health System, where he serves as the Chief of the Nephrology and Hypertension section.

Publications

Research Interest

Dr. Weiner has a long-standing interest in the cellular mechanisms and the regulation of acid-base homeostasis. At present, Dr. Weiner’s laboratory has identified fourteen transporters involved in proton or bicarbonate transport in the renal collecting duct and has examined several characteristics of their regulation.

Dr. Weiner is currently examining the role and regulation of a novel ammonia transporter family of proteins. These proteins, the Rh glycoprotein family, are a component of an extended family of proteins that includes members in all known organisms. Studies from Dr. Weiner’s laboratory to date have demonstrated the presence of these protein in the renal collecting duct, liver and throughout the intestinal tract. Moreover, Dr. Weiner’s studies have shown that carrier-mediated ammonia transport, not non-ionic NH3 diffusion, is the critical component of renal collecting duct ammonia transport. Ongoing studies are examining the physiologic regulation of these proteins and their role in congenital and acquired ammonia transport defects.