Pulmonary, Critical Care, and Sleep Medicine

Pulmonary, Critical Care, and Sleep Medicine Faculty

Najmunnisa Nasreen, M.D. Nasreen Najmunnisa, PhD
Assistant Professor
Division of Pulmonary, Critical Care and Sleep Medicine
Department of Medicine
University of Florida

BOX 100225, Room M453
Gainesville, Florida 32608
Phone: (352)376-1611 ext: 6491
Fax: (352) 271-4559
Email id: nnasreen@medicine.ufl.edu


Educational Background

  • 1992   PhD        Physiology/Biochemistry, Osmania University, INDIA
  • 1986   MS           Zoology, Osmania University, INDIA

Research Interests:

  • Receptor EphA2/EphrinA1 signaling in thoracic malignancies (NSCLC & malignant mesothelioma)
  • Micro RNA regulation in thoracic malignancies
  • Epithelial cell injury and airway remodeling in COPD
  • Pleural mesothelial epithelial mesenchymal transition in lung fibrosis

Professional Societies:

  • American Association of Cancer Research
  • American Thoracic Society
  • American Federation for Medical Research

Editorial activities (invited reviewer):

  • American Journal of Physiology, Lung Cell and Molecular Physiology
  • American Journal of Cellular and Molecular Physiology
  • Cancer
  • Inflammation Research
  • Pharmacological Research
  • Molecular Medicine
  • Cell Death & Differentiation
  • Cell Biology International
  • Cancer Investigation

Grants Funded:

  • Florida Department of Health: Principal Investigator   “Intratumoral Gene Therapy (ITGT) in mouse model for lung cancer”- 2010-2012
  • Florida Department of Health- NIR: Principal Investigator   “Eph-A2 Signaling in Tobacco Smoke Induced Bronchial Airway Epithelial Injury”- 2009-2012
  • GlaxoSmithKline: Co-investigator “Significance of SOCS-3 in airway inflammation in COPD” -2010-2011
  • VA-Merit Review: Consultant “Mechanisms of Development of Pleural Fibrosis"-2011-2014
  • VA-Merit Review: Co-investigator “Mechanisms of Development of Parapneumonic Effusions"-2004-2008
  • Flight Attendant Medical Research Institute: Co-Investigator “Second Hand Smoke (SHS) and airway infection-2007-2010
  • National Institutes of Health: Co-Investigator “Monocyte Recruitment in Pleuro-Pulmonary TB in AIDS” 2001-2006
  • American Association of Lung Cancer: Principal Investigator ““Mechanism of talc induced Pleurodesis” 2003-2004.
  • National Institutes of Health: Co-Investigator “AIDS associated pleural infection” 1999-2004

Representative Publications (selected out of 36):

  • Nasreen N., Hartman D.L., Mohammed K.A., Antony V.B.  Talc Induces Pleural Mesothelial cell Expression of Pro-inflammatory Cytokines and Intercellular Adhesion Molecule-1 (ICAM-1).  Am. J. Respir. Crit. Care Med. 158: 971-978, 1998.
  • Nasreen N., Mohammed K.A., Dowling P.A.,Ward M.J and Antony V.B. Talc Induces Apoptosis in Human Malignant Mesothelioma in vitro. Am. J. Respir. Crit. Care Med. 161(2 Pt 1):595-600, 2000.
  • Nasreen N., Mohammed K.A., Ward M.J.  and Antony V.B. MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells. Amr J Physiol - Lung Cellu Mol Physiol. 278:L591-8, 2000.
  • Nasreen N., Kamal A. Mohammed, Joyce Hardwick, Robert D. Van Horn, Kerry L. Sanders, Hasmeena Kathuria, Farzad Loghmani, and Veena B. Antony. Low molecular weight hyaluronan induces malignant mesothelioma cell (MMC) proliferation and haptotaxis: Role of CD44 receptor in MMC proliferation and haptotaxis. Oncol. Res. An Internatl. J. 13(2):71-78, 2002.
  • Nasreen N., Kamal A. Mohammed, Kerry L. Sanders, Joyce Hardwick, Robert D. Van Horn, Jun tain, Ramit K. Sharma,  Carlos Ramirez-Icaza, Muna M. Kilani, Chade Hage and Veena B. Antony. Pleural Mesothelial cell (PMC) defense mechanisms against malignancy. Oncol. Res. An Internatl. J. 14(3):155-161, 2004.
  • Nasreen N., Mohammed K.A., Scott Brown, Su, Y., Sriram, P.S., Moudgil, B., Loddenkemper, R., and Antony, V.B.  Angiogenic balance in Malignant Pleural Effusions: Talc Mediates switch to angiostasis via Endostatin Induction in Pleural Mesothelial Cells Eur. Resp. Journal.  2007, Apr; 29(4):761-9.
  • Nasreen N., Mohammed K.A., and Antony V.B.Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells.  Cancer. 2006 Nov 15; 107(10):2425-35.
  • Nasreen N., Mohammed K.A., and Antony V.B. Receptor EphA2 activation with ephrinA1 suppresses growth of malignant mesothelioma (MM).  Cancer Lett. 2007 Dec 18; 258(2):215-22.
  • Nasreen N., Mohammed KA, Mubarak KK, Baz MA, Akindipe OA, Fernandez-Bussy S, Antony VB. Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-β1 in vitro. Am J Physiol: Lung Cell Mol Physiol. 2009 Jul;297(1):L115-24.

For a complete list of the publications,
Visit Pubmed, US National Library of Medicine (NLM)

Primary Navigation