Pulmonary, Critical Care, and Sleep Medicine
Pulmonary, Critical Care, and Sleep Medicine Faculty
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Jianliang Zhang, Ph.D. Research Associate Professor Pulmonary, Critical Care, and Sleep Medicine University of Florida College of Medicine 1601 SW Archer Road Gainesville, Florida 32610-0225 Phone (352) 376-1611 ext. 6265 Fax: (352) 374-6170 Email: zhangjl@medicine.ufl.edu |
Educational Background
- 1994 Ph.D. Biochemistry (Molecular Biology), University of Nottingham, England
- 1986 M.Sc. Biochemistry, Hunan Agricultural University, P.R.C
Research Interests
- - Oxidative and nitrosative modulation of endothelial NOS
- - Smoke-induced lung endothelial apoptosis
- - Aging-initiated cell death
Professional Societies
- Scientific Council Member of American Heart Association. 2001-present
- Biochemical Society in U.K. 1991-present
- Member of Society for Free Radical Biology and Medicine. 1998-present
Grants Awarded
American Lung Association: Principal Investigator “Mitochondrial Cytochrome c Oxidase Mechanisms of Smoke-induced Lung Endothelial Cell Death” 2004-2007
Flight Attendant Medical Research Institute: Principal Investigator “Environment Tobacco Smoke-induced Lung Cell Death via the Nitric Oxide-cytochrome c Oxidase Signaling” 2004-2006
Florida Department of Health: Co-Investigator “Tobacco Smoke-Induced Cell Injury in Lung Compartments” 2004-2006
NIH: Co-Principal Investigator “NO Toxicity: Redox Regulation of Lung Cell Thioredoxin" 2001 - 2006
NIH: Co-Principal Investigator “Calreticulin Regulation of Lung Endothelial Cell NOS" 2001 - 2005
Publications (2004 onwards)
- Zhang, J., Jin, B., Li, L., Block, E. R. and Patel, J. M. (2004) NO-induced persistent inhibition and nitrosylation of active site cysteines of mitochondrial cytochrome c oxidase in lung endothelial cells. Am J Physiol Cell Physiol.
- Lu, J. H., Zhang, J., Block, E. R. and Patel, J. M. (2004) Angiotensin IV enhances phosphorylation state of eIF-4E and 4E-BP1 proteins in lung endothelial cells. Molecular and Cellular Biochemistry.
- Li, L., Zhang, J., Block, E. R. and Patel, J. M. (2004) Nitric oxide-modulated marker gene expression of signal transduction pathways in lung endothelial cells. Nitric Oxide Biology and Biochemistry. In Press.
- Gerencser, G. A., Robbins, F., Zhang, J. and Ahearn, G. A. (2004). Electrogenic proton-regulated oxalate/chloride exchange by lobster hepatopancreatic brush-border membrane vesicles. J. Exp. Biol. 207 (Pt 4): 571-578.
- Hu, H., Xin, M., Belayev, L. L., Zhang, J., Block, E.R. and Patel, J. M. (2004) Autoinhibitory domain fragment of endothelial NOS enhances pulmonary artery vasorelaxation by the NO/ cGMP pathway. Am. J. Physiol. (Lung Cell Mol. Physiol. Am J Physiol Lung Cell Mol Physiol 286: L1066-L1074.
For a complete list of the publications,
Visit Pubmed, US National Library of Medicine (NLM)
Honors and Awards
Patents: “DNA encoding a pectin esterase, cells and plants derived therefrom”. USA #: 5, 910, 632; UK # 9403406.3; Canada (pending); PCT international application No. PCT/GB95/00367 (pending)
Books: Patel, J. M., Zhang, J., Li, Y. D. and Block, E. R. (2003) Calreticulin Regulation of Lung Endothelial NOS Activity in Calreticulin in Health and Disease. Pages 205-216. (Eds. P. Eggleton and M. Mitchalak) Landes Bioscience.
Visiting associate professor and member of the Academic Committee/ the Cell Biology textbook editorial board at the Institute of Cell Biology/Department of Cell Biology and Histology & Embryology, Zhejiang University School of Medicine, P.R.C.