Rheumatology & Clinical Immunology
Rheumatology and Clinical Immunology Faculty
Minoru Satoh, M.D., Ph.D.
Research Associate Professor
Education
M.D.: (Iwate Medical College, Morioka, Japan,1981),
Ph.D.: (Keio University, Tokyo, Japan, 1990)
Residency: Keio University Hospital (Tokyo, Japan)
Fellowship: Keio University (Tokyo, Japan)
Areas of interest
Autoimmunity, autoantibodies, systemic lupus erythematosus, scleroderma
Research description
Dr. Satoh has been working on the mechanisms of autoantibody production in systemic lupus erythematosus, scleroderma, polymyositis, and other systemic rheumatic diseases using murine model of lupus as well as samples from autoimmune disease clinic. The laboratory has established a new murine model of lupus, in which lupus-related autoantibodies and immune-complex glomerulonephritis are induced in normal strains of mice regardless of their genetic background by the hydrocarbon oil, pristane. Recent studies focus on the role of antigen presenting cells (macrophages, dendritic cells, B-cells) and cytokine abnormalities in pristane-induced lupus compared with genetically-determine murine lupus in NZB/W F1 and MRL mice.
Representative publications
Satoh M, WH Reeves. Induction of lupus associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane. J. Exp. Med. 180: 2341-2346, 1994
Satoh M,AK Ajmani, T Ogasawara, JJ Langdon, M Hirakata, J Wang, WH Reeves. Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated(IIO) form by a subset of human sera. J. Clin. Invest. 94: 1981-1989, 1994
Satoh M, M Kuwana , T Ogasawara, AK Ajmani, JJ Langdon, D Kimpel, J Wang, WH Reeves. Association of autoantibodies to topoisomerase I and the phosphorylated (IIO) form of RNA polymerase II in Japanese scleroderma patients. J. Immunol. 153: 5838-5848, 1994
Dong X, KJ Hamilton, M Satoh, J Wang, WH Reeves. Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen. J. Exp. Med. 179: 1243-1252, 1994
Satoh M, A Kumar, YS Kanwar, WH Reeves. Antinuclear antibody production and immune complex glomerulonephritis in pristane-treated BALB/c mice. Proc.Natl.Acad.Sci.USA 92; 10934-10938, 1995
Satoh M, JJ Langdon, KJ Hamilton, HB Richards, D Panka, RA Eisenberg, WH Reeves. Distinctive pattern of immune response in human autoimmune sera and MRL/lpr mice sera to U1 small nuclear ribonucleoprotein C protein. J. Clin. Invest. 97: 2619-2626, 1996
Ajmani AK, M Satoh, EA Reap, PL Cohen, WH Reeves. Absence of autoantigen Ku in mature human neutrophils and HL-60 cells and lymphocytes undergoing apoptosis. J. Exp. Med. 181; 2049-2058, 1995
Satoh M, KJ Hamilton, AK Ajmani, X Dong, J Wang, Y Kanwar, WH Reeves. Induction of anti-ribosomal P antibodies and immune complex glomerulonephritis in SJL mice by pristane. J. Immunol. 157: 3200-3206, 1996
Satoh M, HB Richards, KJ Hamilton, WH Reeves. Human anti-nuclear ribonucleoprotein antigen autoimmune sera contain a novel subset of autoantibodies that stabilizes the molecular interaction of U1RNP-C protein with the Sm core proteins. J. Immunol. 158: 5017-5025, 1997
Richards HB, M Satoh, M Shaw, C Libert, V Poli, JC Jennette, WH Reeves. Interleukin-6 dependence of anti-DNA antibody production: Evidence for two pathways of autoantibody formation in pristane-induced lupus. J. Exp. Med. 188: 985-990, 1998
Satoh M, VM Shaheen, PN Kao, T Okano, M Shaw, H Yoshida, HB Richards, WH Reeves: Autoantibodies define a family of phosphoproteins with conserved double stranded RNA binding domains as well as DNA-binding activity. J.Biol.Chem. 274: 34598-34604, 1999
Satoh M, J Weintraub, H Yoshida, VM Shaheen, HB Richards, M Shaw, WH Reeves: Fas and Fas ligand mutation inhibit autoantibody production in pristane-induced lupus. J. Immunol. 165: 1036-1043, 2000